Inhibition of Normal Allogeneic Responder Cells in Mouse Mixed Leukocyte Culture by Long-Passage AKR Leukemic Lymphoblasts1
نویسندگان
چکیده
Responses in unidirectional mixed leukocyte cultures of CBA, C3H/He, A, C57BL/6, and DBA/2 spleen cells to stimulator spleen cells derived from normal AKR mice and from AKR mice bearing a long-passage lymphoblastic leukemia (LAKR) were compared. Thymidine and uridine uptake by allogeneic cells (responder cells) cultured with either mitomycin C treated or X-irradiated LAKR cells (stimulator cells) was significantly lower than uptake by cells cultured with comparably treated normal AKR cells. Uptake by responder cells cultured with a second nonleukemic, allogeneic stimulator population, in addition to LAKR cells, was also diminished, indicating that dimin ished uptake was due to active inhibition, rather than "nonstimulation." Soluble inhibitory factors could not be
منابع مشابه
Inhibition of normal allogeneic responder cells in mouse mixed leukocyte culture by long-passage AKR leukemic lymphoblasts.
Responses in unidirectional mixed leukocyte cultures of CBA, C3H/He, A, C57BL/6, and DBA/2 spleen cells to stimulator spleen cells derived from normal AKR mice and from AKR mice bearing a long-passage lymphoblastic leukemia (LAKR) were compared. Thymidine and uridine uptake by allogeneic cells (responder cells) cultured with either mitomycin C treated or X-irradiated LAKR cells (stimulator cell...
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